TU Ilmenau Humbold Bau


IMI-PainCare: Improving the care of patients suffering from acute or chronic pain. Teilprojekt PROMPT

Universitätsklinikum Jena
Medizinische Fakultät
2018 - 2022
Europäische Union
Bewilligungssumme, Auftragssumme
1.681.833,75 €


PROMPT seeks to improve management of acute and chronic pain by identifying a core set of PROMs which are predictive indicators of treatment success in clinical practice and controlled trials. These will address pain intensities as well as the functional consequences of pain for individuals, and identify patients at risk of experiencing chronification of acute post-operative pain. This will help health care professionals to individualize pain management, and thus improve the quality of life of pain patients. Many RCTs have studied post-operative pain management interventions, but astonishingly, results can often not be validly compared because there is no accepted set of core outcomes. The term “pain intensity” is frequently used but this metric alone is of questionable value to predict long-term consequences, and needs to be expanded to include other PROMs and maybe also outcome measures related to function and side effects. This should enable health care professionals to identify patients with a higher probability of benefiting from particular treatments in clinical practice and RCTs, and so reduce the rate of clinical attrition and accelerate drug development. Furthermore, the correlation of baseline characteristics and a selection of PROMs for specific chronic pain conditions will identify which parameter(s) most reliably predict treatment success.
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