Projektdaten

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DIEMSS - Diet-induced epigenetic modulation and it's impact on sepsis survival

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This project investigates whether diet-induced epigenetic changes can promote metabolic flexibility and improve survival in sepsis. Sepsis is a severe, often fatal condition marked by metabolic and immune dysregulation. A key determinant of survival is the body’s ability to adapt its energy metabolism, particularly when glucose becomes scarce during infection. The study explores how intermittent caloric restriction (ICR) and ketogenic diets (KD) reconfigure chromatin via epigenetic modifications—specifically histone acetylation and ?-hydroxybutyrylation—allowing for the use of alternative energy sources like fatty acids and ketones. These changes could support immune function, reduce oxidative stress, and enhance survival in septic conditions. Using a mouse model, the project assesses metabolic, transcriptional, and epigenetic changes induced by ICR and KD, then evaluates their impact on sepsis progression and survival.