Projektdaten

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Inflammasom-Dysfunktion in der Sepsis und der akuten Nierenschädigung

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A dysregulated host response to infection can lead to sepsis, a life-threatening condition that results in organ failure. The kidneys are among the organs most affected, leading to sepsis-associated acute kidney injury (SA-AKI). Sepsis-associated immune dysregulation is characterized by the coexistence of hyperinflammatory responses and immunosuppression. Immunosuppression summarizes heterogeneous scenarios of an inadequate immune response to invading pathogens, which can affect both innate and adaptive immunity. However, how and which components of the immune response play a major role in sepsis-associated organ failure remains poorly understood. The inflammasome is an important part of the innate immune arsenal and plays a crucial role in the immune response to severe infections and trauma. Dysregulation of the inflammasome has been suggested to contribute to the pathology of severe infections, including COVID-19, and to sepsis-associated organ failure, but the underlying mechanisms are unknown. The clinical observational study Infla-NET-AKI is conducting a systematic analysis of the role of the inflammasome in sepsis-dependent or -independent organ failure and the associated immunosuppression with the aim of better understanding these regulatory processes and targeting them (e.g., by supplementing cytokines and/or the involved inflammasome pathway).