Projektdaten
Development of parallel accumulation – serial fragmentation (PASEF) acquisition modes on a trapped ion mobility (TIMS) mass spectrometer
Hochschule
Universitätsklinikum Jena
Fakultät/Einrichtung
Medizinische Fakultät
Förderkategorie
Länder
Zeitraum
2023 - 2025
Drittmittelgeber
Friedrich-Schiller-Universität Jena
Stichwort
Bewilligungssumme, Auftragssumme
5.000,00 €
Abstract:
Most targeted therapeutics aim to alter the activity of proteins. To better understand how leukemia cells react to these drugs, we aim to develop a scalable and sensitive mass spectrometry-based phosphoproteomics platform that enables time- and dose-dependent drug response profiling. Quantifying drug-dependent signalling pathway engagement on a proteome-wide scale could help elucidating molecular response and resistance mechanisms.